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IBI/Shelton Scientific
230 Long Hill Cross Rd.
Shelton, CT
06484

Manufacturer's Name:                     IBI/Shelton Scientific
                            230 Long Hill Cross Rd.
                            Shelton, CT
                            06484

Emergency telephone:                     Telephone Number for Information
(800) 451-8346                         (800) 253-4942 or (203) 929-8999

Date Prepared: 7-6-00                     Reviewed:

                    Identification                        

Product #: IB70014                     Name: Instapage-19 (19:1 Acryl/Bis
CAS#: N/A Blend                      Soln)                    
                    Toxicity Hazards                    

Hazardous Components:
    Acrylamide                 CAS # 79-06-1        RTECS # AS3325000
    N,N' -Methylenebis (Acrylamide)     CAS # 110-26-9     RTECS # AS3678000
                    Acrylamide                        

Irritation Data
    SKN-RBT     50 MG/ 3D MLD             TXAPA9 6,172,64
    SKN-RBT     500 MG/24H MLD             85JCAE - , 337, 86
    EYE-RBT     10 MG/30S RINSE MLD         TXAPA9 6, 172, 64
    EYE-RBT     100 MG/24H MOD             28ZPAK - , 54, 72
Toxicity Data
    ORL-RAT     LD50: 124 MG/KG             AMPMAR 36, 58, 75
    SKN-RAT     LD50: 400 MG/KG             GISAAA 44 (10), 73, 79
    IPR-RAT     LD50: 90 MG/KG             AMPMAR 36, 58, 75
    UNR-RAT     LD50: 208 MG/KG             GISAAA 43 (9), 38, 78
    ORL-MUS     LD50: 107 MG/KG             ARTODN 47, 179, 81
    IPR-MUS     LD50: 170 MG/KG              TXAPA9 33, 142, 75
    UNR-MUS     LD50: 156 MG/KG             GISAAA 43 (9), 38, 78
    ORL-RBT    LD50: 150 MG/KG             TXAPA9 6, 172, 64
    UNR-RBT     LD50: 280 MG/KG             GISAAA 43 (9), 38, 78
    ORL-GPG    LD50: 150 MG/KG             TXAPA9 6, 172, 64
    SCU-GPG     LD50: 170 MG/KG             MELAAD 47, 192, 56
    UNR-GPG     LD50: 173 MG/KG             GISAAA 43 (9), 38, 78
    ORL-QAL     LD50: 186 MG/KG             JTEHD6 7, 935, 81
    ORL-MAM     LD50: 100 MG/KG             KASEAA 17, 495, 79





Reviews, Standards and Regulations
    ACGIH TLV-Suspected Carcinogen 85INA8 5, 12, 86
    ACGIH TLV-TWA 0.03 MG/M3 (skin) 85INA8 5, 12, 86
    IARC Cancer Review: Animal Sufficient Evidence IMEMDT 39, 41, 86
    IARC Cancer Review: Human No Adequate Data IMEMDT 39, 41, 86
    IARC Cancer Review: Group 2B IMSUDL 7, 56, 87
    MSHA Standard-Air: TWA 0.3 MG/M3 (skin) DTLVS* 3, 5, 71
    OSHA PEL: 8H TWA 0.3 MG/M3 (skin) FEREAC 54, 2923, 89
    OSHA PEL FINAL: 8H TWA 0.03 MG/M3 (skin) FEREAC 54, 2923, 89
    OEL-AUSTRALIA: TWA 0.3 MG/M3; Skin; Carcinogen January 1993
    OEL-BELGIUM: TWA 0.3 MG/M3; Skin; Carcinogen January 1993
OEL-DENMARK: TWA 0.3 MG/M3; Skin; Carcinogen January 1993
OEL-FINLAND: TWA 0.3 MG/M3; Stel 0.9 MG/M3 January 1993
OEL-FRANCE: TWA 0.3 MG/M3 January 1993
OEL-GERMANY; Skin; Carcinogen January 1993
OEL-HUNGARY: Stel 0.3 MG/M3; Skin; Carcinogen January 1993
OEL-JAPAN: TWA 0.3 MG/M3; Skin January 1993
OEL-RUSSIA: Steel 0.2 MG/M3; Skin January 1993
OEL-SWEDEN: TWA 0.3 MG/M3; Stel 0.9 MG/M3; Skin, January 1993
OEL-SWITZERLAND: TWA 0.3 MG/M3; Skin; Carcinogen January 1993
OEL-THE NETHERLANDS: TWA 0.3 MG/M3; January 1993
OEL-THE PHILLIPPINES: TWA 0.3 MG/M3; Skin January 1993
OEL-UNITED KINGDOM: TWA 0.3 MG/M3; Stel 0.6 MG/M3; Skin, January 1993
OEL in Bulgaria, Colombia, Jordan, Korea, New Zealand, Singapore, Vietnam, Check ACGIH TLV.
NIOSH REL to Acrylamide-Air: 10H CA TWA 0.3 MG/M3 (SK) NIOSH* DHHS #92-100, 92.
    NOHS 1974: HZD 03540; NIS 10; TNF 442; NOS 24; TNE 7047
    NOES 1983: HZD 03540; NIS 19; TNF 453; NOS 22; TNE 10651; TFE 721
EPA Genetox Program 1988, Positive: Cytogenetics-Male Germ Cell
EPA Genetox Program 1988, Negative: In Vivo Cytogenetics-Nonhuman Bone Marrow
EPA Genetox Program 1988, Inconclusive: In Vivo Sce-Nonhuman
EPA TSCA Chemical Inventory, June 1990
EPA TSCA 8 (A) Preliminary Assessment Information, Final Rule FEREAC 47, 26992, 82
EPA TSCA Section 8 (E) Status Report 8EHQ-0783-0488
EPA TSCA Section 8 (E) Status Report 8EHQ-0785-0560
On EPA Iris Database
EPA TSCA Test Submission (TSCATS) Data Base, January 1993
NTP 7TH Annual Report On Carcinogens, 1992: Anticipated To Be Carcinogen.
OSHA Analytical Method #21
Target Organ Data
    Peripheral Nerve and Sensation (flaccid paralysis without anesthesia)
    Behavioral (altered sleep time)
    Behavioral (tremor)
    Behavioral (convulsions or effect on seizure threshold)
    Behavioral (change in motor activity)
    Behavioral (muscle contraction or spasticity)
    Lungs, Thorax, or Respiration (tumors)
    Gastrointestinal (nausea or vomiting)
    Blood (other changes)
    Skin and Appendages (tumors)
    Paternal Effects (spermatogenesis)
    Paternal Effects (testes, epididymis, sperm duct)
    Effects on Fertility (male fertility index)
    Effects on Fertility (pre-implantation mortality)
    Effects on Fertility (post-implantation mortality)
Effects on Embryo or Fetus (fetotoxicity)
Effects on Embryo or Fetus (fetal death)
Specific developmental abnormalities (musculoskeletal system)
Tumorigenic Effects (testicular tumors)
Tumorigenic Effects (uterine tumors)
Effects on Newborn (growth statistics)
Effects on Newborn (biochemical and metabolic)
Tumorigenic (carcinogenic by RTECS criteria)
Tumorigenic (Neoplastic by RTECS criteria)
Biochemical Effects (transaminases)
Biochemical Effects (peptidases)
_______________________N, N' -METHYLENEBIS (ACRYLAMIDE)__________________

TOXICITY DATA:
    ORL-RAT    LD50: 390 MG/KG             37ASAA 1, 306, 78
ORL-MUS    LD50: 401 MG/KG             ARTODN 47, 179, 81    
REVIEWS, STANDARDS, AND REGULATIONS:
    NOHS 1974: HZD 83963; NIS 4; TNF 199; NOS 5; TNE 2098
    NOES 1983: HZD 83963; NIS 2; TNF; 10; NOS 3; TNE 66; TFE 35
    EPA TSCA Chemical Inventory June 1990
    EPA TSCA Section 8(E) Status Report 8EHQ-0880-0357
    EPA TSCA Test Submission (TSCATS) Data Base, January 1993
TARGET ORGAN DATA
    Paternal Effects (spermatogenesis)
    Paternal Effects (testes, epididymis, sperm duct)
    Effects on Fertility (pre-implantation mortality)
    Effects on Fertility (post-implantation mortality)
Only selected registry of toxic effects of chemical substances (RTECS) data is presented      here. See actual entry in RTECS for complete information.
                    Health Hazard Data                    

ACUTE EFFECTS:
    Harmful if swallowed, inhaled, or absorbed through skin.
    May cause eye and skin irritation
    May cause nervous system disturbances
CHRONIC EFFECTS:
    May alter genetic material.
    Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.
    Carcinogen.






FIRST AID:
In case of contact, immediately flush eyes or skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes.
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
If swallowed, wash out mouth with water provided person is conscious.
Call a physician immediately.
                    Physical Data                        

Appearance and Odor: Liquid
                Fire and Explosion Hazard Data                    

Extinguishing Media
    Carbon dioxide, dry chemical powder or appropriate foam.
Special Firefighting Procedures
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Use water spray to cool fire-exposed containers.
Unusual Fire and Explosions Hazards
    Container explosion may occur under fire conditions.
Emits toxic fumes under fire conditions.
                    Reactivity Data                        

Incompatibilities
    Avoid contact with acid
    Bases
    Oxidizing agents.
    Air and moisture sensitive
    Store away from heat and direct sunlight.
    May polymerize on exposure to light.
Hazardous Combustion or Decomposition Products
Thermal decomposition may produce carbon monoxide, carbon dioxide, and nitrogen oxides.
                Spill or Leak Procedures                    

Steps To Be Taken If Material Is Released Or Spilled
    Evacuate area.
Wear self-contained breathing apparatus, rubber boots and heavy rubber gloves.
Dike spill site. Use inert material to absorb spill.
    Sweep up, place in a bag and hold for waste disposal.
    Avoid raising dust.
    Ventilate area and wash spill site after material pickup is complete.
Waste Disposal Method
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local laws.
            Precautions to be taken in Handling and Storage                
   
Wear appropriate NIOSH/MSHA-approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Use only in a chemical fume hood.
Safety shower and eye bath.
Do not breathe mists or vapors.
Do not get in eyes, on skin, on clothing.
Avoid prolonged or repeated exposure.
Readily absorbed through skin.
Wash thoroughly after handling.
Keep tightly closed.
Store in a cool dry place.
Poison
May cause cancer.
May cause heritable genetic damage.
Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes and skin.
Possible teratogen.   
Neurological hazard.
May cause nervous system disturbances.
Target organ(s):
    Nerves
    Male reproductive system
    Sensitive to light
    Do not breathe mists or vapors.
    If you feel unwell, seek medical advice (show the label where possible)
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. After contact with skin, wash immediately with plenty of water. Take off immediately all contaminated clothing.
Wear suitable protective clothing, gloves, and eye/face protection.
Label Precautionary Statement
    POISON
    SUSPECTED CARCINOGEN
    NEUROTOXIN
This product is subject to Sara Section 313 reporting requirements.
Judgements as to the suitability of information herein for purchaser's purpose are necessarily the purchaser's responsibility. Therefore, although reasonable care has been taken in the preparation of such information, Shelton Scientific extends no warranties, makes no representation and assumes no responsibility as to the accuracy or suitability of such information for application to purchaser's to purchaser's intended purposes or for consequences of its use.